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PLATELET-RICH PLASMA and Platelet rich fibrin
One of the exciting areas of dental research is the use of a patient’s own concentrated healing plasma to accelerate healing in implants and oral surgery
The use of platelet rich plasma instilled into a third molar extrication site virtually eliminates complications of healing such as “dry socket.
Wound healing can be enhanced and speeded by the use of a platelet gel that is harvested from the patient’s own plasma a few minutes before it is used. The Platelet Rich Plasma (PRP) consists of
- · concentrated fibrin,
- · stem cells, and
- · platelets
Resulting in up to a five-fold increase in platelets and bioactive growth factors.
The platelet gel contains healing factors:
• EGF (Epidermal Growth Factor)
• GF (Insulin Growth Factor)
• BFGF (Basic Fibroblast Growth Factor)
• VEGF (Vascular Endothelial Growth Factor)
• CTGF (Connective Tissue Growth Factor)
• PGDF (Platelet Derived Growth Factor)
• TGF-β (Transforming Growth Factor-beta)
and stimulates and attracts stem cells to migrate to the healing site. New discoveries are discovered with regularity.
The exact mechanisms of action of the various players in components of wound healing are not fully understood yet. Ideal ratios of the components of PRP preparations still are being investigated, and more clinical research with long-term results is needed.
concentrated platelet rich plasma acts as a tissue growth stimulant, enhancing the natural process of tissue repair and healing.
Studies show that platelet rich plasma produces new
- · Collagen
- · Bone
- · Cartilage
at the site of the injection.
Thea newer extract known as Platelet rich fibrin (PRF) is a second generation platelet concentrate widely used to accelerate soft and hard tissue healing. Its advantages over the better known platelet-rich plasma (PRP) include ease of preparation/application, minimal expense, and lack of biochemical modification (no bovine thrombin or anticoagulant is required). PRF is a strictly autologous fibrin matrix containing a large quantity of platelet and leukocyte cytokines.
This case presentation demonstrates how PRF may be used in site preservation procedures.